摘要
We synthesized optically active 2-(8′-diphenylphosphino-1′-naphthyl)oxazoline ligands by palladium-catalyzed coupling reactions of (trimethylsilyl)diphenylphosphine with 2-(8′-bromo-1′-naphthyl)oxazolines, which, in turn, were prepared from 8-bromo-1-naphthoyl chloride by the reaction with natural optical active amino alcohols. Pd-Catalyzed allylic alkylation reaction induced by these chiral ligands gave the allylic substituted products in high yields and moderate ee values.
We synthesized optically active 2-(8′-diphenylphosphino-1′-naphthyl)oxazoline ligands by palladium-catalyzed coupling reactions of (trimethylsilyl)diphenylphosphine with 2-(8′-bromo-1′-naphthyl)oxazolines, which, in turn, were prepared from 8-bromo-1-naphthoyl chloride by the reaction with natural optical active amino alcohols. Pd-Catalyzed allylic alkylation reaction induced by these chiral ligands gave the allylic substituted products in high yields and moderate ee values.
基金
theMajorStateBasicResearchDevelopmentProgram (No .2 0 0 0 0 775 0 0 ) ,theNationalNaturalScienceFounda tionofChina ,ChineseAcademyofSciences ,ShanghaiMunicipalCommitteeofScienceandTechnology ,andWangKuanchengPost doctoralWorkAwardFoundation
