摘要
Novel thiophosphoramidate derivatives of nucleoside analogue as membrane-soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′-O, O′-Isopropylidene uridine-5′-yl N-thiophosphoryl serine and threonine methyl esters underwent the intramolecular catalyzed hydrolysis reaction.
Novel thiophosphoramidate derivatives of nucleoside analogue as membrane-soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′-O, O′-Isopropylidene uridine-5′-yl N-thiophosphoryl serine and threonine methyl esters underwent the intramolecular catalyzed hydrolysis reaction.
基金
theNationalNaturalScienceFoundationofChina (Nos .2 990 2 0 0 3and 39870 415 ) ,theMinistryofScienceandTechnology ,theEducationMinistryofChinaandDoctorCandidateInnovationFoundationinTsinghuaUniversity (No .0 92 430 30 5 )
