摘要
A formal synthesis of (+)-cassiol using (1S,2S)-2-amino-1-(4-nitrophenyl)-1,3-propanediol as chiral auxiliary is reported. The quaternary chiral center in the molecule was constructed by sequential alkylation of a bicyclic lactam (prepared from the aforementioned auxiliary and 5-oxo-heptanoic acid) with methyl iodide and benzyloxymethyl chloride.
A formal synthesis of (+)-cassiol using (1S,2S)-2-amino-1-(4-nitrophenyl)-1,3-propanediol as chiral auxiliary is reported. The quaternary chiral center in the molecule was constructed by sequential alkylation of a bicyclic lactam (prepared from the aforementioned auxiliary and 5-oxo-heptanoic acid) with methyl iodide and benzyloxymethyl chloride.
基金
theMajorStateBasicResearchDevelopmentProgramofChina (No .G2 0 0 0 0 775 0 2 ) ,theNationalNaturalScienceFoundationofChina (Nos.2 0 0 2 5 2 0 7and 2 9832 0 2 0 ) ,andtheLifeScienceSpecialFundofChineseAcademyofSciencesSupportedbytheMinistryofFinance (
