摘要
New chiral substituted 8-quinolinyl-oxazoline ligands have been synthesized and applied in the copper(I)-catalyzed asymmetric cyclopropanation of styrene with alkyl diazoacetates. The steric effect in the ligands plays a significant role in the enantiocontrol in asymmetric cyclopropanation, while the electronic effect is less important.
New chiral substituted 8-quinolinyl-oxazoline ligands have been synthesized and applied in the copper(I)-catalyzed asymmetric cyclopropanation of styrene with alkyl diazoacetates. The steric effect in the ligands plays a significant role in the enantiocontrol in asymmetric cyclopropanation, while the electronic effect is less important.
基金
theNationalNaturalScienceFoundationofChina (No .2 0 132 0 10 ) ,theMajorStateBasicResearchDevelopmentProgram (No.G2 0 0 0 0 775 0 6 ) ,theEducationMinistryofChinaandtheNaturalScienceFoundationofTianjin
