Synthesis of 2-Benzylthio-5-phenyl-3,4-disubstituted Thiophenes by Intramolecular Condensation of α-Oxo Ketene Dibenzyl^thioacetals 被引量：1

Synthesis of 2-Benzylthio-5-phenyl-3,4-disubstituted Thiophenes by Intramolecular Condensation of α-Oxo Ketene Dibenzyl^thioacetals

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摘要 A facile route to 2-benzylthio-5-phenyl-3,4-disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α-oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed. A facile route to 2-benzylthio-5-phenyl-3,4-disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α-oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed.

作者王芒艾林张继余刘群高连勋

出处《Chinese Journal of Chemistry》 SCIE CAS CSCD 2002年第12期1591-1597,1464,共0页 中国化学（英文版）

基金 theNationalNaturalScienceFoundationofChina (No. 2 986 2 0 0 4),theScienceandTechnologyDevelopmentProgramFoundationofJilinProvince (No.2 0 0 10 5 0 5)andtheYouthFoundationofNortheastNormalUniversity (No.111379)

关键词 α-oxo ketene dithioacetals α-oxo ketene dibenzylthioacetals multisubstituted thiophenes intramolecular aldol type condensation α-oxo ketene dithioacetals α-oxo ketene dibenzylthioacetals multisubstituted thiophenes intramolecular aldol type condensation

分类号 O626 [理学—有机化学]

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参考文献10

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同被引文献3

1Mei Xin ZHAO,Qun LIU,Fu Shun LIANG,Jing Fu LIU,Bao Zhong ZHAO,LianZhong LI,(Department of Chemistry, Northeast Normal University, Changchun, 130024)(Department of Chemistry, Jilin Teacher college, Jilin, 131000).α-Oxoketene Cyclic S, S-cetals Chemistry-Substitution Reaction of α,α'-Dicinnamoyl Ketene Cyclic S, S-Acetals with Ethylenediamine[J].Chinese Chemical Letters,1998,9(3):231-232. 被引量：2
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3艾林,肖幼萍,刘群,张前,王芒.α,α-二乙酰基二苄硫缩烯酮的碱催化脱乙酰基反应及缩合反应机理研究[J].高等学校化学学报,2004,25(5):877-879. 被引量：2

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1郭孟萍,肖道安,陈三宝,周兰姜.3-[双(苯甲硫基)亚甲基]-2，4-戊二酮的合成和晶体结构[J].化学试剂,2014,36(3):283-285. 被引量：1

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7徐显秀,王芒,刘群,潘玲,赵玉龙.Azo-coupling Decarboxylation Reaction of α-Carboxy Ketene Dithioacetals in Water-a New Route to 1,2-Diaza-1,3-butadienes[J].Chinese Journal of Chemistry,2006,24(10):1431-1434. 被引量：1
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Chinese Journal of Chemistry

2002年第12期

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Synthesis of 2-Benzylthio-5-phenyl-3,4-disubstituted Thiophenes by Intramolecular Condensation of α-Oxo Ketene Dibenzyl^thioacetals 被引量：1

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