严重感染患者急性时相蛋白的临床研究

The clinical study of acute phase protein in severe infection patient

目的 为了探讨急性时相蛋白在严重感染患者发病过程中的变化及其诊断价值。方法 采用全自动散射比浊定量分析法测定30例严重感染患者CRP.α_1—AT、α_1—AG及HP的含量和动态变化,并与30例轻症医院感染患者及30例正常人对照分析,结果 严重感染患者首次测定CRP、α_1—AT,α_1—AG及HP含量均显著高于轻症感染组和正常组(P值分别<0.01)。动态观察发现急性时相蛋白随着病情好转逐渐降至正常范围,轻症感染患者仅α_1—AG差异显著(P<0.05)。结论 CRP、α_1—AT、α_1—AG及HP的定量分析能尽早发现医院感染,准确判断其严重程度及预后具有重要价值。CRP持续升高、α_1—AG和HP迅速下降则提示病情恶化。

Objective The acute phase protein and its diagnostic value in severe infection patients were studied. Methods Serum concentration of CRP, α_1-AT, α_1-AG and HP were detected by quantitative analysis of laser nephelometry in 30 severe and 30 mild infected and 30 un-infected patients. Results The serum levels of CRP, α_1-AT, α_1-AG and HP increased significantly in severe patients(P<0.01)and were gradually down to normal levels with patient condition improving. Levels of α_1-AG increased only in mild infected patients. Conclusion Quantitative analysis of CRP, α_1-AT, α_1-AG and HP is a rapid and sensitive methods and valuable in the early assessment of severity and prognosis of infection.