P^(53)、bcl-2蛋白在原发性肺鳞癌中的表达及临床意义

The Expression and Follow-up Significance of P53、Bcl-2 Protein in Lung Squamous Carcimoma Patients

目的 探讨P^(53)、bcl-2蛋白在原发性肺鳞癌中的表达及意义。方法 应用免疫组化方法检测了经5年随访的66例肺鳞癌P^(53)、bcl-2蛋白的表达。结果 P^(53)、bcl-2蛋白在肺鳞癌中的阳性表达率分别为56.1％和27.3％,其中21例有淋巴结癌转移的阳性率分别为61.9％和28.6％。P^(53)和bcl-2蛋白均阳性表达者预后显著差于阴性表达者(P<0.01)。结论 P^(53)和bcl-2蛋白的异常表达与肺鳞癌的生物学行为和随访存活期密切相关,并可作为评估预后的有效指标。

Objective To study the clinical pathologic significance of P53,bcl-2 expressions of squamous carcinoma in lung. Methods Expressions of P(53)and bcl-2 proteins were determinated with immunohistochemistry in 66 cases of squamous cancer in lung. Results Positive rates of P^(53)\\\\\\\\bcl-2 protein of 66 cases were 56. 1% and 27. 3%, respectively. Amount of them, the positive rates of P53、bcl-2 expressions in 21 cases of lymph node metastasis group were 61.9% and 28.6%, respectively. The poor prognosis of patiens with P53、bcl-2 positive expressions were showed by the follow-μp material. Conclusion Expressions of P53and bcl-2 proteins in lung squamous carcinoma are correlated with the malignant progression and put the important role on predicting the prognosis lung squamous cancer patients.