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Feasibility of Using Chitosan in Nerve Repair 被引量:1

Feasibility of Using Chitosan in Nerve Repair
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摘要 WTFZ] The chemical composition and microstructure of a biocompatible material prepared from chitosan were evaluated using FTIR and SEM techniques. Its mechanical and physical properties were also tested. The materials nerve cell affinity and peripheral nerve repair feasibility were also evaluated. In vitro cytotoxicity tests indicated that both cerebral cortex cells and endothelial cells (ECs) can attach to the surface and grow well. These results indicate that chitosan has the necessary properties for an artificial nerve conduit material and may be a promising candidate for the design of a bioactive, biodegradable nerve conduit.[ WTFZ] The chemical composition and microstructure of a biocompatible material prepared from chitosan were evaluated using FTIR and SEM techniques. Its mechanical and physical properties were also tested. The materials nerve cell affinity and peripheral nerve repair feasibility were also evaluated. In vitro cytotoxicity tests indicated that both cerebral cortex cells and endothelial cells (ECs) can attach to the surface and grow well. These results indicate that chitosan has the necessary properties for an artificial nerve conduit material and may be a promising candidate for the design of a bioactive, biodegradable nerve conduit.[
出处 《Tsinghua Science and Technology》 SCIE EI CAS 2000年第4期432-435,共4页 清华大学学报(自然科学版(英文版)
基金 the State Science and TechnologyComm ission!(No. 819- 0 7- 0 1)
关键词 ZK(]chitosan nerve repair biocompatibili ZK(]chitosan nerve repair biocompatibili
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参考文献6

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同被引文献11

  • 1Khor E;Lim L Y.Implantable applications of chitin and chitosan[J],2003(13).
  • 2Cheng M;Cao W;Gao Y;Gong Y, Zhao N, Zhang X.Studies on nerve cell affinity of biodegradable modified chitosan films,2003(10).
  • 3Awad H A;Wickham M Q;Leddy H A;Gimble J M Guilak F.Chondrogenic differentiation of adipose-derived adult stem cells in agarose,alginate,and gelatin scaffolds[J],2004(16).
  • 4Gronthos S;Franklin D M;Leddy H A;Robey P G, Storms R W, Gimble J M.Surface protein characterization of human adipose tissue-derived stromal cells[J],2001(01).
  • 5Zhang L H;Yang F;Gong Y D;Zhao N M Zhang X F.Cultivation of vascular smooth muscle cells on chitosan and gelatin films[J]Acta Biophysica Sinica,2004(01).
  • 6Dragoo J L;Choi J Y;Lieberman J R;Huang J, Zuk P A, Zhang J, Hedrick M H, Benhaim P.Bone induction by BMP-2 transduced stem cells derived from human fat[J],2003(04).
  • 7Zuk P A;Zhu M;Mizuno H;Huang J Futrell J W Katz A J Benhaim P Lorenz H P Hedrick M H.Multilineage cells from human adipose tissue:Implications for cell-based therapies[J],2001(02).
  • 8Zuk P A;Zhu M;Ashjian P;De Ugarte D A, Huang J I, Mizuno H, Alfonso Z C, Fraser J K, Benhaim P, Hedrick M H.Human adipose tissue is a source of multipotent stem cells[J],2002(12).
  • 9Zhao F;Yin Y;Lu W W;Leong J C Zhang W Zhang J Zhang M Yao K.Preparation and histological evaluation of biomimetic three-dimensional hydroxyapatite/chitosan-gelatin network composite scaffolds[J],2002(15).
  • 10Eser Elcin A;Elcin Y M;Pappas G D.Neural tissue engineering:Adrenal chromaffin cell attachment and viability on chitosan scaffolds[J],1998(07).

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