摘要
To evaluate the role of p27 Kip1 in tumorigenesis and the development of trophoblastic cell disease MethodsUsing immunohistochemistry, the expression of p27 protein was investgated in 10 normal chorionic villi in the first trimester of pregnancy, 15 complete hydatidiform moles (HM), 7 invasive moles (IM) and 7 choriocarcinomas (CC) Results In all cases, immunohistochemical staining localized p27 protein in the plasma Decreased expression of p27 Kip1 was observed in malignant trophoblastic neoplasms with a positive rate of 21 43%, which is significantly less than that in normal chorionic villi (80%) and in complete HM (73 33%) ( P <0 05) The positive rate of p27 Kip1 in those complete HM with large uterine size for gestational age was lower than that in those with normal or small uterus (42 86% vs 100%, P <0 05) Conclusion p27 Kip1 may be involved in the tumorigenesis of gestational trophoblastic neoplasm as a negative regulator of the cell cycle The expression level of p27 Kip1 in trophoblastic cells may be a prognostic factor for complete HM
To evaluate the role of p27 Kip1 in tumorigenesis and the development of trophoblastic cell disease MethodsUsing immunohistochemistry, the expression of p27 protein was investgated in 10 normal chorionic villi in the first trimester of pregnancy, 15 complete hydatidiform moles (HM), 7 invasive moles (IM) and 7 choriocarcinomas (CC) Results In all cases, immunohistochemical staining localized p27 protein in the plasma Decreased expression of p27 Kip1 was observed in malignant trophoblastic neoplasms with a positive rate of 21 43%, which is significantly less than that in normal chorionic villi (80%) and in complete HM (73 33%) ( P <0 05) The positive rate of p27 Kip1 in those complete HM with large uterine size for gestational age was lower than that in those with normal or small uterus (42 86% vs 100%, P <0 05) Conclusion p27 Kip1 may be involved in the tumorigenesis of gestational trophoblastic neoplasm as a negative regulator of the cell cycle The expression level of p27 Kip1 in trophoblastic cells may be a prognostic factor for complete HM
