摘要
Obejctive To develop a Chinese-made electrolytic detachable coil (CEDC) that would allow patients to enjoy the benefit of electrolytic detachable coil without having to rely on the expensive Guglielmi detachable coil (GDC), and to test the safety and efficiency of CEDC Methods Radiopacity of the marker of the CEDC was tested The anti strain force of coils and connection points were measured In vitro and in vivo electrolyses were conducted We produced 21 aneurysm models including lateral, bifurcation, and terminal aneurysm models, and embolized 18 models with CEDC Results Radiopacity of the marker was satisfactory Anti strain of the coil and the connection point have shown the safety and efficiency of CEDC Electrolysis in vitro and vivo, was similar to that of GDC 83% of the aneurysm models were completely occluded Coils were found to induce thrombosis in the aneurysm cavity, and could lead to a new endothelium over the entrance of the aneurysm, with organized tissue replacing thrombosis in 2 months Conclusions CEDC is as efficient and safe as GDC The marker, the ability to induce thrombosis inside the sac and the growth of new endothelium over the orifice are very satisfactory
Obejctive To develop a Chinese-made electrolytic detachable coil (CEDC) that would allow patients to enjoy the benefit of electrolytic detachable coil without having to rely on the expensive Guglielmi detachable coil (GDC), and to test the safety and efficiency of CEDC Methods Radiopacity of the marker of the CEDC was tested The anti strain force of coils and connection points were measured In vitro and in vivo electrolyses were conducted We produced 21 aneurysm models including lateral, bifurcation, and terminal aneurysm models, and embolized 18 models with CEDC Results Radiopacity of the marker was satisfactory Anti strain of the coil and the connection point have shown the safety and efficiency of CEDC Electrolysis in vitro and vivo, was similar to that of GDC 83% of the aneurysm models were completely occluded Coils were found to induce thrombosis in the aneurysm cavity, and could lead to a new endothelium over the entrance of the aneurysm, with organized tissue replacing thrombosis in 2 months Conclusions CEDC is as efficient and safe as GDC The marker, the ability to induce thrombosis inside the sac and the growth of new endothelium over the orifice are very satisfactory
基金
TheresearchwassupportedbytheNationalProgramforKeyScienceandTechnologyProject
the 9thFive YearPlan (No .96 90 7 0 2 0 2 )
