摘要
Objective To determine the location of a putative tumor suppressor gene (TSG), and evaluate the frequency loss of heterozygosity (LOH) of the long arm of chromosome 9 (9q) in bladder cancer Methods We analyzed 25 patients with bladder cancer for LOH of 9q using 25 high density microsatellite markers Results Twenty three samples (92%) showed LOH at least at one locus on 9q We identified that the commonly deleted region were at 9q12 q21, 9q22, and 9q34 The rate of LOH was 44 0%, 22 7%, 22 7%, 16 0%, 12 0% on DBH, D9S15, D9S1815, D9S1831, D9S176 locus, respectively, and was not significantly related with grades and stages of tumor Conclusion These data suggest that alteration of a TSG at DBH of 9q may play an important role in the development of bladder cancer
Objective To determine the location of a putative tumor suppressor gene (TSG), and evaluate the frequency loss of heterozygosity (LOH) of the long arm of chromosome 9 (9q) in bladder cancer Methods We analyzed 25 patients with bladder cancer for LOH of 9q using 25 high density microsatellite markers Results Twenty three samples (92%) showed LOH at least at one locus on 9q We identified that the commonly deleted region were at 9q12 q21, 9q22, and 9q34 The rate of LOH was 44 0%, 22 7%, 22 7%, 16 0%, 12 0% on DBH, D9S15, D9S1815, D9S1831, D9S176 locus, respectively, and was not significantly related with grades and stages of tumor Conclusion These data suggest that alteration of a TSG at DBH of 9q may play an important role in the development of bladder cancer
