原发性中枢神经系统淋巴瘤临床和病理分析

Clinical and pathological features of primary central nervous system lymphoma

目的分析原发性中枢神经系统淋巴瘤的临床和病理特征。方法:对9例原发性中枢性神经系统恶性淋巴瘤(PC- NSL)患者(男5例,女4例,年龄39～70岁,平均54.6岁)的临床、影像学与病理学特征进行分析。结果:PCNSL临床表现复 杂,颅内高压为主要临床表现之一,头颅CT以及MRI检查显示中枢侵及额叶多见。PCNSL主要起源于B细胞,综合治疗效 果好,中位生存期为15个月。结论:PCNSL临床与影像学缺乏特异性表现,脑活组织病理学检查是确诊本病的主要手段,活 检确诊后积极放化疗可取得较好的效果。

Objective:To study the clinical,radiological and pathological features of primary central nervous system lym-phoma(PCNSL).Methods:The clinical,laboratory,neuroradiological and pathological data of9patients with PCNSL were analyzed retrospectively.Results:Increased intracranial pressure was the main clinical findings of PCNSL.CT and MRI showed solitary or multiple intracranical masses in the frontal lobe.PCNSL was mostly of B-cell origin.The outcome of com-prehensive treatment was favorable.Conclusion:PCNSL patients usually do not show characteristic clinical manifestation or findings in imaging scanning.Brain biopsy and pathological examination might be more reliable than others.Comprehensive treatment including radiotherapy and chemotherapy can achieve good effects.[