噪声诱发心理应激对大白鼠组织中肌酐、尿素氮的影响

INFLUENCE OF NOISE-INDUCED PSYCHOLOGICAL STRESS ON THE LEVELS OF CREATININE AND UREA NITROGEN IN RATS

目的：研究噪声诱发短期与长期心理应激对动物脑、肝、肺、心、肾组织中的肌酐和尿素氮的堆积及其对组织的影响。方法：将SD－大白鼠随机分为空白、5天、10天和20天组，并用噪声对其进行干扰．诱发心理应激反应后处死动物，检测以上组织中的肌酐和尿素氮水平。结果：心理应激可以造成动物上述组织中肌酐和尿素氮代谢的变化。结论：①在急性应激期，以上各器官都参与因心理应激而诱发的代谢反应，且可产生适应性反应。②各组织中尿素氮的代谢平衡在长期应激时趋于稳定，但这种稳定是建立在较高水平基础上。③尿素氮代谢平衡失调引起氨类物质在脑组织中的堆积，而对脑组织所产生影响可能是动物心理应激性行为障碍的重要因素。

objective To study the influence of short-term or long -term noise-induced psychological stresson the creainine and urea nitrogen levels in brain, liver, heart and kidney tissues of rats Methods Forty SD-rats were divided into four proups , ten rats in each group .Rats in three of the four groups were stimulated by noises for five , ten and twenty days respectively. The other one group was studied as control . All rats were killed after the simulation , and the levels of creatinine and urea nitrogen in the relevant tissues were determined . Results Psychological stress caused the metabolic changes of creatinine and urea nitrogen in the relevan tissues . Conclusion ① In acute stress period , the relevant organs all participate in metabolic reactions induced by psychological stress , and evolve a adjustrnent reaction to the psychological stress in the meantime .② The metabolic balance of the creatinine and urea nitrogen tend to be stable in the long-term strere, but the stabilization is in a high level .③ Metabolic dysequilibrium of urea nitrogen can cause accumulation of ammonia in the brain tissue , and the accumulation could be the main factor that cause the behavior disorder of psychololgical stress .