摘要
目的 :观察何首乌颗粒 (Heshouwu Granule,HG)对亚急性衰老大鼠睾丸 PCNA表达的影响。方法 :D-半乳糖 (D- gal)连续腹腔注射制作亚急性衰老大鼠模型 ,检测 HG灌胃前后模型大鼠血清睾酮含量及睾丸生精细胞 PCNA表达的变化情况。结果 :D-半乳糖致亚急性衰老大鼠血清睾酮含量及睾丸PCNA阳性细胞率明显下降 ,与正常大鼠比较差异显著 (P<0 .0 5 ,P<0 .0 1 ) ;经 HG灌胃后 ,二者均升高接近正常水平 ,与模型大鼠相比有明显差异 (P<0 .0 5 ,P<0 .0 1 )。结论 :HG可提高亚急性衰老大鼠血清睾酮含量及睾丸生精细胞 PCNA表达水平 。
Objective:To study the effect of Heshouwu Granule (HG) on PCNA expression in testes of sub acutely aging rats.Methods: The sub acutely aging rats were made by injecting D gal into abdominal cavity continually. Then the testosterone level in serum and PCNA expression in testes were observed before and after taking HG. Results: The testosterone level in serum and PCNA expression in testes decreased significantly after injecting D gal continually compared with normal rats (P<0.05,P<0.01); these two indexes all increased obviously after taking HG compared with sub acutely aging rats (P<0.05,P<0.01). Conclusion: HG can increase the testosterone level in serum and PCNA expression in testes of sub acutely aging rats, HG has fairly effect on delaying senescence.
出处
《承德医学院学报》
2004年第2期102-103,共2页
Journal of Chengde Medical University
