肝癌、胆管癌患者血清微量元素及酶活性水平的研究

DETECTION OF LEVEL OF FOUR MICROELEMENTS AND ACTIVITIES OF ENZYMES IN SERA OF PATIENTS WITH HEPATOCARCINOMA AND CHOLANGIO-CARCINOMA

对23例肝癌,11例胆管癌患者血清Zn、Cu、Mn、Cd含量进行测定分析,同时测定丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)活性,并同36例健康人作对照比较。结果显示:肝癌、胆管癌血清Cu、Mn、Cd含量明显高于对照组(P<0.01),血清Zn低于对照组(P<O.01),Cu、Zn比值增高;肝癌ALT、AST、GGT、ALP明显高于对照组(P<O.01);胆管癌AST、ALP、GGT明显高于对照组(P>O.05),而ALT与正常对照组无显著性差异(P>0.05)。以上结果提示血清Cu、Mn、Cd、Zn含量及AKP、GGT、AST、ALT活性的联合检测可作为肝癌、胆管癌诊断、疗效观察及预后的参考指标。

It was detected the levels of Zn, Cu, Mn and Cd in sera of 23 hepatoarcinoma patients and 11 cholangiocarcinoma ones, and the activities of their serum alanine aminotransferase (ALT), as-partate aminotransferase (AST), alkaline phosphatase (ALP) and r -glutamyl transpeptidase (7 -GGT) at the same time. The same items as above which were used as the control, were detected in 36 healthy persons. The results showed that levels of Cu, Mn. Cd of the patients were obviously higher and Zn was lower than those of the controls (P<0. 01). The activities of four detected enzymes of 23 hepatocarcinoma patients were significantly higher than those of the controls (P<0. 01). The activities of AST. ALP and r-GGT of cholangiocarcinoma patients were higher than those of the controls (P< 0. 01), but ALT was not significantly different from that of the controls. It was recommended that these items could be used as the reference indexes in diagnosis, therapeutic observation and prognosis of hepatocarcinoma and cholangiocarcinoma.