^(153)Sm—EDTMP治疗恶性肿瘤骨转移

^(153)Sm-EDTMP IN TREATMENT FOR PAINFUL BONE METASTASIS

目的:观察^(153)Sm—EDTMP[^(153)钐乙二胺四亚甲基膦酸(EDTMP)]治疗恶性肿瘤骨转移的疼痛和活动障碍的疗效。方法:43例恶性肿瘤骨转移病人(男性32例,女性11例),年龄58.21±11.63岁,应用^(153)Sm—EDTMP治疗2～5次。结果:止痛有效率79.07％。合并化疗、放疗或以骨膦为主的生物治疗者较单用^(153)Sm—EDTMP者疗效好。对活动障碍的有效率为51.16％。结论:应用^(153)Sm—EDTMP治疗恶性肿瘤骨转移病人,能有效减轻病人疼痛,改善活动障碍。

Objective:To investigate effect of 153Sm -EDTMP on treatment for painful bone metastasis. Method: 43 patients with malignant bone metastasis (32 men and 11 women) who had accepted therapy of 153Sm -EDTMP two to five times were researched. Their mean age was 58. 21± 11. 63 years. Result: The analgesic rate was 79. 07% (34/43). Those patients who had also accepted chemotherapy, radiotherapy or bonefoes had better effect. The effective rate of improving motion disturbance was 51. 16%(17/32%), Conclusion: 153Sm-EDTMP is effective, less side-effect and safe in the treatment for painful bone metastasis.