穿孔素与疾病

Perforin and Disease

穿孔素（ＰＦＰ）是ＣＴＬ和ＮＫ赖以溶解和杀伤靶细胞的一种糖蛋白。有关研究表明，ＰＦＰ参与了机体对恶变细胞的免疫监视及抗感染作用，其免疫调节作用与维持免疫自稳和防止发生自身免疫病有关。ＰＦＰ介导的对正常功能细胞的免疫病理损伤与移植排斥、心肌炎等多种疾病相关。已发现一些可调节ＰＦＰ表达和细胞毒作用的细胞因子和化学药物，为相关疾病的治疗和预防带来了希望。

Perforin (PFP) , a kind of glycoprotein , plays a crucial role in CTL and NK mediated cytolysis. Studies have already demonstated the immunologic surveillance and anti infection function of PFP. Its role of immune regulation can promote the body's immunologic homeostasis ,therefore it is invovled in preventing autoimmune disease . PFP can also cause immunopathalogical damage to normal cells in many disease such as transplantation rejection or myocarditis. It has been found that some kinds of cytokine and chemical can modulate the expression and cytolytic activity of PFP.This will bring hope to the therapy of PFP involed diseases.