盐酸班布特罗口服液治疗支气管哮喘的评价

Efficacy evaluation of hydrochloric bambuterol solution for treating bronchial asthma

目的：评价新型长效β２激动剂——盐酸班布特罗口服液治疗支气管哮喘的疗效和安全性。方法：采用随机单盲对照和开放试验，对１０１例哮喘患者进行为期４周、口服盐酸班布特罗口服液、１０～２０ｍｇ每晚一次的疗效观察，并进行剂量滴定。结果：治疗组（５０例）和开放组（５１例）临床控制率分别为５４．０％和６２．５％，有效率分别为８８．０％和９２．７％。治疗２周，肺功能即显著改善。剂量滴定试验提示部分患者的合适剂量为每日２０ｍｇ。不良反应发生率为７．９％。主要表现为手抖、心悸和头晕，不影响治疗。１例出现一过性血清丙氨酸转氨酶（ＡＬＴ）轻度升高。结论：盐酸班布特罗口服液是安全而有效的，是一种长效支气管扩张药物。

Objectives: To evaluate efficacy of hydrochloric bambaterol solution for treating asthma. Methods: Using randomized, singleblind control and open trial, 101 cases were treated by hydrochloric bambuterol for 4 weeks ,10￣20 mg,oncedaily evening,and titrated by dosage . Results: The clinical control rate in trial group(50 cases) and open group(51 cases) was 54.00% and 62.75%,respectively,the efficacy rate was 88.00% and 92.16%,respectively.The lung function was significantly improved by the end of 2 weeks,The dosage titration suggested that the appropriate dose was 20 mg/d in some of the patients. The frequency of adverse reaction was 7.9% involving tremor,palpitation and dizziness. The treatment may be continued.The ALT was mild abnormal in one case of trial group. Conclusions: The hydrochloric bambuterol solution is a safe and efficient longacting bronchodilator.