动脉粥样硬化症与肺炎衣原体感染——91例尸检结果报告

Atherosclerosis and infection of chlamydia pneumoniae 91 cases autopsy report

目的：调查国内动脉粥样硬化症患者肺炎衣原体感染的状况。方法：尸检取主动脉粥样硬化病灶与非硬化病灶组织，应用套式ＰＣＲ技术检测血管组织中的肺炎衣原体特异性基因扩增产物。结果：病理证实伴动脉粥样硬化症的８８例尸检主动脉组织中，３４例检出肺炎衣原特异性基因扩增产物，阳性率达３８．６％；ＤＮＡ序列分析表明，基因扩增产物与肺炎衣原体标准菌株基因序列完全一致。结论：我国动脉粥样硬化症患者主动脉血管组织中存在肺炎衣原体感染，感染率与国外报道相近，其临床意义有待深入探讨。

Objectives: To evaluate the incidence of chlamydia pneumoniae infection in domestic atherosclerosis. Methods: The technique of nested polymerase chain reaction for detect specific DNA of chlamydia pneumoniae. Results: 34 of 88 autopsy with atherosclerosis were positive(38.6%). The specificity of the PCR amplified product was confirmed by DNA sequence analysis technique. Conclusions: Our study reveals that the infection rate of chlamydia pneumoniae is up to 40% at least in the patients with atherosclersis and the results are similar with abroad reports,but the significance and relationship between infection of chlamydia pneumoniae and atherosclerosis waited for further research.