慢性肾功能衰竭血液透析对纤维蛋白原的影响

Hemodialysis effect on fibrinogen in he patients with chronic enal insufficiency

目的:观察血透对慢性肾功能衰竭患者血浆纤维蛋白原的影响。方法:纤维蛋白原采用计算机自动检测系统,D-二聚体采用ELISA法,FDP采用纸片凝集法。结果:20例慢性肾功能衰竭透析前、后各项数值分别为:FMPV 0.569±0.130,0.680±0.150;Amax 0.281±0.055,0.345±0.065;S(g/L)3.15±0.70,3.98±0.85;DT(S)15±3,20±4;FMDV/Amax 2.024,1.971;D-二聚体(mg/L)0.905,0.995;FDP(mg/L)6.06,6.76;结论:慢性肾功能衰竭患者血浆中纤维蛋白原水平、功能及纤溶活力均高于正常对照,血透后各项指标不能改善甚至仍有上调。

Objective: To detect Hemodialysis effect on fibrinogen in the patients with chronic renal insufficiency. Method: Fibrinogen was detected with a computer autoanalyzer, D - dirner was detected with EIJSA method. Paper coagulation method was used to detect FDP. Result: Before and after blood penetration(20 cases chronic renal insufficiency patients), the values of fibrinogen function were respectively FMPV 0.569±0. 130, 0.680± 0.150; Amax 0.281 ±0.055, 0.345±0.065; S(mg/dl)315± 70, 398 ±85; DT(s)l5± 3, 20±4; FMDV/Aax2.024, 1.971; D-dimer(mg/L) 0.905, 0.995; FDP(mg/L) 6. 06, 6.76. Conclusion: The fibrinogen level, fibrinogen function and fibrinolytic vitality all higher than those of control. After blood penetration, the above - mentioned values not improved and the values increased.