免疫抑制酸性蛋白与肺癌的关系

Relations between Immunosuppressive Acid Protein and Lung Cancer

目的 :探讨血清免疫抑制酸性蛋白 (IAP)含量与肺癌发生的关系。方法 :采用放射免疫法 (RIA) ,检测 2 1例肺癌患者血清IAP的含量 ,并与 4 2例肺部炎性疾病患者及 2 0例健康人对照分析。结果 :肺癌组血清IAP含量及异常率均明显高于肺部炎性疾病组及健康人 (P <0 .0 1及P <0 .0 0 1和 χ2 =12 .60 5 2 ,P <0 .0 0 5 )。结论 :血清IAP在肺癌的早期诊断、监测临床疗效和预后等方面是有一定参考价值的肺瘤标记物。

Objective: To evaluate the relation between serum immunosuppressive acid protein (IAP) content and occurrence of lung cancer. Methods: The serum IAP content of 21 patients suffering from lung cancer was detected by RIA and compared with that of 42 patients with lung inflammatory diseases and 20 healthy volunteers. Results: Both the content of serum IAP and the abnormality rate of the lung cancer group were significantly higher than those of the lung inflammation group and healthy volunteers (P< 0.01 , P<0.01 and χ 2=12.6052, P<0.005). Conclusion: The serum IAP may be a valuable tumour marker in the early diagnosis, monitoring of clinical effects, and prognosis of the lung cancer.