用放射免疫测定法分析牙周洁治与唾液中前列腺素的关系

Analysis of the Relationship between Periodontal Scaling and Prostaglandins in Saliva by Radioimmunoassay

目的 :探讨牙周洁治对唾液中前列腺素 (PGs)的影响及牙周洁治的作用机理。方法 :选牙周炎 (PE)、牙龈炎 (G)和健康人 (H)各 10例 ,用放射免疫测定法分析牙周洁治前后患者唾液中 6 -酮 -前列腺素Fla(6 -K -PGFla)含量 ,比较治疗前后各组及组间 6 -K -PGFla含量的变化。结果 :洁治前不同牙周病组间患者唾液中 6 -K -PGFla含量比均有显著性差异 ;洁治后PE组患者唾液中 6 -K -PGFla与G组和H组均有显著性差异 ,G组与H组无显著性差异 ;洁治前后PE组患者唾液中6 -K -PGFla相比有非常显著性差异 ,洁治后G组患者唾液中 6 -K -PGFla含量比洁治前明显减少 ,H组患者唾液中 6 -K-PGFla含量在治疗后有轻度降低 ,但与治疗前比无显著差异。结论 :牙周洁治对不同牙周病患者唾液中 6 -K -PGFla含量均有明显的抑制作用 ,对牙龈炎患者的抑制作用最强 ;其作用机理是通过调节机体唾液中的 6 -K -PGFla等PGs含量而起治疗作用。

Objective: To study the effect of periodontal scaling on the content of 6 keto prostaglandin Fla(6 K PGFla) in saliva of patients with periodontal diseases and its mechanism of action. Methods: 10 patients with periodontitis(PE), 10 patients with gingivitis (G) and 10 healthy persons (H) were selected;the content of 6 keto prostaglandin Fla(6 K PGFla) in saliva of each patient was measured by radioimmunoassay (RIA); and the difference between the three groups before and after scaling were compared. Results: The difference in salivary 6 K PGFla between periodontal disease groups was significant before scaling. There was a significant difference in salivary 6 K PGFla between group PE and group G or group H after scaling. However, there was no significant difference between group G and group H. The difference was also found significant after comparing the content of 6 K PGFla in group PE before and after scaling. 6 K PGFla was more decreased after scaling than before scaling in group G.Comparing the content of 6 K PGFla in group H before and after scaling,the difference was not found significant. Conclusion: There was a marked inhibitive effect of periodontal scaling on the content of 6 K PGFla in the saliva of the patients with different periodontal diseases and the effect was more significant in group G than others. The mechanism of action of scaling was more related to the inhibition of 6 K PGFla in saliva.