载脂蛋白E基因多态性与老年血管性痴呆的关系

Relationship Between Apolipoprotein E Gene Polymorphism and Vascular Dementia in the elderly

为探讨载脂蛋白E(Apo E)基因多态性与血管性痴呆(VD)的关系,采用聚合酶链式反应——限制性片段长度多态性(PCR-RFLP)技术检测了28例VD患者的ApoE基因型,并与40例同龄健康人对照组比较,同时检测血脂及部分血浆载脂蛋白水平。结果表明,VD组与对照组之间,ε_4基因频率无显著性差异。提示ε_4基因与VD的发生无密切关系。

Objective To study the relationship between apolipoprotein E(Apo E) gene polymorphism and vascular dementia(VD). Methods Polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) was used to detect Apo E genotype in 28 patients with VD and 40 age-matched controls. Meanwhile, the serum levels of lipids and some apolipoproteins were determined. Results There are no significant difference between VD and age-matched controls in the frequency of ε4 allele.Conclusion The data suggest that e4 is not associated with the development of VD.