云克(^(99)Tc-MDP)治疗Graves’眼病19例临床疗效观察

The Clinic Observation of ^(99)Tc-MDP Therapy in Graves’ Ophthalmopathy

目的 观察云克 (99Tc -MDP)对Graves’眼病的疗效和安全性 ,探索其新的治疗方法。方法 19例Graves’眼病患者 ,均进行了碘 - 131治疗 ,其中 10例在碘 - 131治疗前即有突眼 ,5例在治疗过程中出现突眼 ,4例在甲亢治愈或甲低时出现突眼 ,其中突眼病史 3年以上的 3例 ,1～ 3年 6例 ,1年以下的 10例。每次静脉注射云克两套共 10mg ,每 2天注射 1次 ,2 0套为 1个疗程 ,2～ 4个疗程后观察疗效和副作用。结果 云克对Graves’眼病具有较好的疗效 ,其总有效率为 89.5 % ,显效率 36 .8% ,而且突眼程度越轻、突眼病史越短则疗效越好 ;相反 ,突眼程度越重、突眼病史越长则疗效越差。治疗过程中未见明显副作用。结论 云克治疗Graves’眼病安全、有效、副作用小 ,应尽早应用云克对Graves’眼病进行

Objective To observe the therapeutic efficacy and security of Graves’ ophthalmopathy(GO) treated with 99Tc-MDP and probe a new therapy for it. Methods Nineteen patients with Graves’ ophthalmopathy were all treated with iodine-131, ten of them having GO before the iodine-131 therapy, five of them having GO during iodine-131 treatment, and four of them having GO when the hyperthyroidism were cured or hypothyroidism were occurred. Three of them had over three years of ophthalmoptosis, six of them had one to three years of ophthalmoptosis,ten of them had beyond one year of ophthalmoptosis.They were all injected into venous with two pairs of 99Tc-MDP (the total dosage was 10mg) every two days, one course of treatment is twenty days and continues 2-4 courses, then observe the therapeutic efficacy and side effects on them. Results 99Tc-MDP had quite good therapeutic efficacy to GO. The effective rate and notable effective rate was 89.5% and 36.8%. The lighter was the degree of ophthalmoptosis and the shorter was the history of ophthalmoptosis, the better was the therapeutic efficacy. On the contrary, the more serious was the degree of ophthalmoptosis and the longer was the history of ophthalmoptosis, the less was the therapeutic efficacy. Any side effects was not observed during the treatment. Conclusions The 99Tc-MDP therapy in Graves’ ophthalmopathy is safe, effective and having no side effects.It should be used to GO patients as soon with more than three courses of dosage.