nm23-H1在非小细胞肺癌中的表达及与淋巴结转移的关系

Expression of nm23 H1 in Non Small Cell Lung Cancer.and Its Correlation with Lymph Node Metastasis

目的：研究８４例非小细胞肺癌中ｎｍ２３－Ｈ１的表达及与淋巴结转移的关系，探讨其在非小细胞肺癌中表达的意义及预后的联系。方法：用免疫组化ＬＳＡＢ方法检测肺癌石蜡组织中ｎｍ２３－Ｈ１的表达；结果：５９．６％的腺癌和５４．１％的鳞癌有ｎｍ２３－Ｈ１的表达；在有淋巴结转移的肺癌中ｎｍ２３－Ｈ１表达的阳性率为２１．９％，而无淋巴结转移的肺癌中其表达率高达７８．８％，两者差异有显著性。结论：ｎｍ２３－Ｈ１的表达与非小细胞肺癌的淋巴结转移呈负相关，其可能抑制淋巴结的转移过程，是观察预后的一个重要指标。

Objective To investigate the expression of nm23 H1 innon small cell lung cancer.and its relationship with lymph node metastasis Method With immunohistochemical analysis.Results The results showed that 59 6% of the adenocarcinomas and 54 1% of the aquamous cell carcinomas had the expression of nm23 H1,and there was no significant difference between them.Only 21 9% of the lung cancer with metastasis of lymph nodes had the expression of nm23 H1,but 78 8% with no metastasis had the expression of nm23 H1.And the difference between them was significant.Conclusion It suggests that the expression of nm23 H1 is negativety correlated to metastasis in lymph nodes of non samll cell lung cancer,it may inhibit the metastasis process of lymph nodes,and can be considered as one of the indexes for the prognosis of non small cell lung cancer.