摘要
目的：研究ｎｍ２３－Ｈ１表达与口腔鳞癌转移间的关系。方法：应用免疫组化ＳＰ法检测了４０例口腔鳞癌ｎｍ２３－Ｈ１的表达。结果：ｎｍ２３－Ｈ１在口腔鳞癌中有较高的表达，阳性率为６７．５％（２７／４０）；淋巴结转移组ｎｍ２３－Ｈ１的阳性率为４０％（４／１０）；非淋巴结转移组ｎｍ２３－Ｈ１的阳性率为７６．７％（２３／３０），两组差异有显著性（Ｐ＜０．０５）。结论：ｎｍ２３－Ｈ１在抑制口腔鳞癌转移中具有一定的作用并可望成为指示口腔鳞癌淋巴结转移的一个新指标。
Objective:To investigate the expression of
nm23 H1 in oral squamous cell carcinoma and the relationship between nm23 H1 expression
and metastasis.Methods:The SP immunohistochemical method was used to study the
expression of nm23 H1 in 40 cases of oral squamous cell carcinoma.Result:The expression
level of nm23 H1 in oral squamous cell carcinoma was high,the positive rate was 67
5%(27/40).Among them,in 10 cases of oral squamous cell carcinoma with lymphatic metastasis,
40%(4/10) cases were nm23 H1 positive;in 30 cases of oral squamous cell carcinoma without
lymphatic metastasis,76 7%(23/30)cases were nm23 H1 positive,Compare to group with
lymphatic metastasis,the differatiation was significant ( P <0.05).Conclusions nm23 H1 has
some inhibitory effect on the metastasis of oral squamous cell carcinoma and nm23 H1 may be
considered as a useful index judging presence of metastasis. [
出处
《中国民康医学》
1999年第3期22-23,64,共3页
Medical Journal of Chinese People’s Health
