摘要
目的：研究ＣｙｃｌｉｎＤ１、Ｐ５３蛋白在口腔鳞癌中的表达及与口腔鳞癌发生、发展间的关系。方法：应用免疫组化ＳＰ法，检测了４０例口腔鳞癌中ＣｙｃｌｉｎＤ１、Ｐ５３蛋白的表达情况。结果：５７．５％（２３／４０）的口腔鳞癌ＣｙｃｌｉｎＤ１过表达。正常口腔粘膜Ｐ５３蛋白均为阴性；５２．５％（２１／４０）的口腔鳞癌Ｐ５３蛋白阳性，两组间差异有显著性（Ｐ＜０．０５）。其中高分化鳞癌阳性率为３６．８％（７／１９）；中分化鳞癌阳性率为６６．７％（１４／２１），差异具有显著性（Ｐ＜０．０５）。结论：ＣｙｃｌｉｎＤ１过表达及Ｐ５３蛋白异常协同作用引起口腔鳞癌细胞的失控性生长，在口腔鳞癌的发生、发展中发挥着重要的作用。
Objective: To investigate the expression of cyclin
D1P53 in oral squamous carcinoma (OSC) and the relationship between cyclin D1P53
expression to carcinogenesis and progression of OSC. Methods: The SP immunohistochemical
method was used to study the exprssion of cyclin D1P53 in 40 cases of OSC. Results:
23CASES(575%,23/40)of OSC were cyclin D1 overexpression. 10 cases (100%) of normal oral
mucosa were p 53negative; 21 cases (525%,21/40) of OSC were P53positive. Compare to
normal oral mucosa, the difference was significant (P<005).Among them, 7 cases (368%,7/19) of
welldifferentiated OSC were P53positive; 14 caese (667%,14/21) of moderatedlydifferentiated
OSC were P53positive, the difference was significant (P<005). Conclusion:The overexpression
of cyclin D1 and abnormality of P53 protein may play a crucial role in carcinogenesis and
progression of oral squamous carcimoma.
出处
《中国民康医学》
1999年第4期32-33,58+65,共4页
Medical Journal of Chinese People’s Health
