红细胞膜脂质成分的变化与正常妊娠的关系

Relationship between the Change of Erythrocyte Membrane Lipid Component and Normotensive Pregnancy

目的：探讨正常妊娠期间红细胞膜脂质成分的变化。方法：采用比色法、全自动生化分析仪及气相色谱法对22例正常妊娠妇女及24例健康未妊娠妇女进行了红细胞膜磷脂、胆固醇及八种脂肪酸含量的测定。结果：正常妊娠组红细胞膜胆固醇、磷脂及胆固醇／磷脂的比值均高于健康未妊娠组，但无统计学意义（P＞0.05）；红细胞膜八种脂肪酸含量在两组间亦无显著差异（P＞0．05）。结论：正常妊娠组红细胞膜胆固醇、磷脂含量的升高可能是血清脂质变化的反映，正常妊娠组红细胞膜脂质成分的这种变化不影响红细胞变形性、全血粘度及子宫──—胎盘微循环的灌注。

Objective To study the change of normtensive pregnant women erythrocyte membrane lipidcomponent. Methods The cholesterol and phospholipid content, eight fatty acid composition of erythrocyte membrane in 24 non - pregnant healthy women, 22 normotensive pregnant women were determined using automatic biochemical analyser, gas chromatography and modified colorimentric methed.Results The cholesterol, phospholipid content and cholesterol/ phospholipid (C/ P ) ratio of the erythro cyte membrane were no significant difference between normotensive pregnant group and non - pregnant healthy women group (P >0. 05). The eight fatty acid composition of erythrocyte membranewere no significant difference between the two groups(P>0. 05 ). Conclusion The increase of cholesterol, phospholipid content of erythrocyte membrane probably reflected the change of serum lipid content.