双歧杆菌对脾虚小鼠肠道菌群的调整作用

The Regulative Role of Bifidobacterium in the Intestinal Flora of Spleen Insuffciency Mice

目的：观察双歧杆菌对大黄致脾虚小鼠肠道菌群的调整作用。方法：大黄致脾虚造模型法和粪菌群定量检测法，结果：在大黄造模组小鼠肠道菌群中，双歧杆菌、类杆菌和乳酸杆菌的数量下降，大肠杆菌的数量上升（P＜0.05），经灌服双歧杆菌制剂（108／ml，1ml/天）一周后，以上各菌群数量恢复正常。结论：服用双歧杆菌制剂有改善机体牌虚证的作用。

To observe the regulative role of Bifidobacterium in the intestinal flora ofspleen insufficiency mice. Methods The mice model of spleen insufficiency were established by oral administration of Daihuang (Rheum palmatum) decoction . The counts of fecal flora were determined.Results The counts of Bifidobacterium, Bacteroides and Lactobacillus, were decreased and E. coli wasincreased in the feces of spleen insufficiency mice (P<0. 05). After the mice ingested B. bifidum (108/ml) for one week, 1ml/day, the counts Of fecal flora were restored to normal level. ConclusionBifidobactrium possesses the effects of adjusting the intestinal flora of mice and promting the recoveryof the mice with spleen insufficiency.