胃溃疡模型大鼠颌下腺的5-HT及其受体与胃溃疡自愈的关系

RELATIONSHIP BETWEEN 5 HYDROXYTRYPTAMTINE AND ITS RECEPTOR OF SUBMAXILLARY GLANDS AND THE AUTOHEAL ING OF EXPERIMENTAL GASTRIC ULCER IN RAT

为观察胃溃疡模型大鼠颌下腺５－ＨＴ及其受体相对含量的变化，探讨二者与胃溃疡自愈的关系。采用免疫组织化学ＡＢＣ法和原位定量测定法。结果显示：胃溃疡模型大鼠颌下腺５－ＨＴ相对含量于手术后１０天已有升高，２０天达到高峰，３０天已显示出下降，分别与盐水对照组的同一时间点的相比较，均有显著性差异（Ｐ值分别小于０．０１）。５－ＨＴＲ的相对含量也呈现出类似的变化。推测颌下腺的５－ＨＴ可能参与了胃溃疡的愈合过程，其受体在颌下腺的含量的增多，提示前者可能对后者的合成与释放起着重要的作用。

By using immunohistochemical ABC method and in situ sem quantitative measure method, the relative content changes of 5 hydroxytryptamine(5 HT) and its receptor in submaxillary gland of experimental gastric ulcer model rats were observed. The results showed that the relative contents of 5 HT and its receptor in submaxillary glands of experimental gastric ulcer groups and physiological saline control groups changed at the same time phases, these substances began to increase at 10th day after operation, and rose to peak value at 20th day after operation and fell down at 30th day after operation. But during the three time phases, the contents of 5 HT and 5 HTR in experimental gastric ulcer groups were signifficantly higher than those in physiological saline control group 5 HT In submaxillary glands may involve the regulation of gastric ulcer autohealing.