摘要
Objective: To study the correlations between human leukocyte antigen (HLA) and osteosarcoma in Chinese Han nationality. Methods: The frequencies of HLA A, B, DR, DQ locus antigens were tested in a group of 25 osteosarcoma patients in comparison with 250 healthy controls by using complement dependent microlympho cytotoxity technique. Both of them are Chinese Han nationality. The results were compared statistically. Results: The frequency of HLA B35 was 0.400 in patient group, and comparing with 0.048 in controls. The relative risk of suffering from osteosarcoma in persons carrying HLA B35 was 13.220 times as high as that in those without this antigen ( P <0.01). Patients with HLA B13 had increased in the relative risk of poor prognosis with 12.048 fold comparing with those without this antigen ( P <0.05). A tendency of the worst prognosis was presented in the patients who carry both HLA B13 and HLA B35. For those patients with HLA B40, the relative safety was 7.057 times higher than the negative persons ( P <0.05). Conclusion: HLA B35 is in close linkage to osteosarcoma susceptibility genes in Chinese Han nationality. HLA B13 and HLA B40 may be associated to the malignant and resistant genes of osteosarcoma respectively.
Objective: To study the correlations between human leukocyte antigen (HLA) and osteosarcoma in Chinese Han nationality. Methods: The frequencies of HLA A, B, DR, DQ locus antigens were tested in a group of 25 osteosarcoma patients in comparison with 250 healthy controls by using complement dependent microlympho cytotoxity technique. Both of them are Chinese Han nationality. The results were compared statistically. Results: The frequency of HLA B35 was 0.400 in patient group, and comparing with 0.048 in controls. The relative risk of suffering from osteosarcoma in persons carrying HLA B35 was 13.220 times as high as that in those without this antigen ( P <0.01). Patients with HLA B13 had increased in the relative risk of poor prognosis with 12.048 fold comparing with those without this antigen ( P <0.05). A tendency of the worst prognosis was presented in the patients who carry both HLA B13 and HLA B35. For those patients with HLA B40, the relative safety was 7.057 times higher than the negative persons ( P <0.05). Conclusion: HLA B35 is in close linkage to osteosarcoma susceptibility genes in Chinese Han nationality. HLA B13 and HLA B40 may be associated to the malignant and resistant genes of osteosarcoma respectively.
