Telomerase activity in gastric cancer and its clinical implications 被引量：25

Telomerase activity in gastric cancer and its clinical implications *

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摘要ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆｃａｒｃｉｎｏｍａｒｅｓｕｌｔｓｆｒｏｍｍｕｌｔｉｐｌｅｉｎｄｅｐｅｎｄｅｎｔｇｅｎｅｔｉｃｃｈａｎｇｅｓｔｈａｔａｃｔｉｖａｔｅｐｒｏｔｏｏｎｃｏｇｅｎｅｓｏｒｉｎａｃｔｉｖａｔｅｔｈｅａｃ... AIM To study the telomerase expression in gastric carcinoma and its clinical implications. METHODS Telomerase activity was examined in gastric cancer and corresponding normal tissues using a modified TRAP (telomeric repeat amplification protocol) assay (TRAP eze) in tissue samples from 94 gastric carcinomas and 58 normal tissues, 12 gastric adenomas and 9 gastric ulcer lesions. RESULTS Telomerase activity was present in 81 of the 94 (86 2%) gastric cancer tissues, whereas no telomerase activity was detected in any normal tissues. The incidence of telomerase activity in gastric cancer tissues was unrelated to the tumor diameter, histological grade, tumor invasion in depth, lymph node metastasis and TNM stage. CONCLUSION Telomerase plays an important role in carcinogenesis and progression of gastric cancer, and it is suggested to be a useful tumor marker.

作者 ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG Jian Ping, ZHENG Zhang Qing and WANG Lei

出处《World Journal of Gastroenterology》 SCIE CAS CSCD 1999年第4期44-47,共4页 世界胃肠病学杂志（英文版）

关键词 STOMACH NEOPLASMS TELOMERASE TUMOR MARKERS stomach neoplasms telomerase tumor markers

分类号 R735.2 [医药卫生—肿瘤]

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Telomerase activity in gastric cancer and its clinical implications 被引量：25

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