摘要
Structural effect of substituents directly bonded to carbanions bearing a phosphorate moiety is examined. Nucleophihc addition of phosphonate carbanion to 1-nitroalkene followed by subsequent reaction with chlorotrimethylsilane leads to a series of 2-isoxazoline based on the formation of an alkene and silyl nitronate as a 1,3-dipole. On the other hand, addition of carbanion derived from isocyanomethylphosphonate to nitroalkene with the formation of nitronate followed by intromolecular cyclization provides substituted phosphoryl pyrroles.
Structural effect of substituents directly bonded to carbanions bearing a phosphorate moiety is examined. Nucleophihc addition of phosphonate carbanion to 1-nitroalkene followed by subsequent reaction with chlorotrimethylsilane leads to a series of 2-isoxazoline based on the formation of an alkene and silyl nitronate as a 1,3-dipole. On the other hand, addition of carbanion derived from isocyanomethylphosphonate to nitroalkene with the formation of nitronate followed by intromolecular cyclization provides substituted phosphoryl pyrroles.
基金
Project (No. 29672042, 29832050) supported by the National Natural Science Foundation of China.
