摘要
目的 为了探讨老年病毒性肝炎患者血清可溶性白细胞介素Ⅱ受体(sIL—2R)的变化及其在诊断、病情演变和预后判断中的意义。方法 采用夹心酶联免疫吸附法测定82例老年病毒性肝炎患者血清sIL-2R的水平。结果 sIL-2R的水平在急性病毒性肝炎(AH)、慢性迁延型肝炎(CPH)、慢性活动型肝炎(CAH)、肝炎后肝硬化(HC)和重型肝炎(SH)中分别为643.5±232.6u/ml、452.8±234.3u/ml、632.5±243.3u/ml、693.5±267.3u/ml和901.4±304.8u/ml。病例组 sIL-2R的水平均明显高于对照组(P<0.01)。肝炎活动期均明显(P<0.05),各型肝炎间无明显差异。结论 老年人各型肝炎患者血清中sIL-2R都明显增高,其水平高低在一定程度上反映了机体免疫功能状态,肝细胞损伤及炎症程度。
Objective To study the alteration of serum soluble interleukin -2 receptor in old patients with viral hepatitis, and to look for a reliable basis of diagnosis, evolution of illness and judgement of prognosis. Methods The level of solu-ble interleukin -2 receptors (sIL - 2R) were measured by an enzyme linked immunosorbent assay in 82 old patients of viral hepatitis. Results Among the total,the serum sIL -2R levels in the cases of acute viral hepatitis (AH) .chronic persistent hepatitis (CPH),chronic active hepatitis (CAH), posthepatitis cirrhosis (HO and severe hepatitis(SH) we±re 643. 5±232. 6u/ ml52. 8±234. 3u/ml,632. 5±243. 3u/ml,193. 5±267. 3u/ml and 901. 4±304. 8u/ml respectively, which were higher than that of normal control (P<0. 01). The sIL -2R levels in acteric stage of acute viral hepatitis were significantly higher than that of recovery stage(P<0. 05). No significant difference was found among hepatitis type A,B,C and E. Conclusion The serum sLL - 2R levels in old patients with viral hepatitis are increased obviously, reflecting the patients' immune function, degree of liver cells damage and inflammation.
出处
《青岛医药卫生》
1999年第1期11-12,共2页
Qingdao Medical Journal
