缺血性中风后的新血管形成

Neovascularization after Ischemic Stroke

缺血性中风后缺血组织周围即半暗带存在新血管形成。这些新血管形成涉及血管新生、动脉形成和血管系生成三种机制。缺血性中风后新血管形成是一个复杂的病理过程 ,它受到促进和抑制新血管形成因素的严格调控。如血管内皮生长因子、血小板衍生生长因子、碱性成纤维细胞生长因子、血管生成素等可以刺激血管新生 ,而凝血酶敏感蛋白等可能抑制血管新生。缺血性中风后新血管形成可能使中风后神经功能恢复 ,所以治疗性新血管形成开始应用于缺血性中风的动物模型。

After ischemic stroke, there is neovascularization around the infarcted area, which is called penumbra. Angiogenesis and arteriogenesis are responsible for the new vessel formation. Until recently, vasculogenesis has been proved to involve mechanisms in postischemic neovascularization, which was thought to be restricted to embryonic development. New blood vessels' formation is a complex pathologic process after ischemic stroke, in which many factors are properly involved. There are factors stimulating neovascularization, such as vascular endothelial growth factor, platelet-derived growth factor, basic fibroblast growth factor and angiopoietin; there are also factors inhibiting neovascularization, such as thrombospondin. Functional recovery was found after stroke, which may contribute to angiogensis in the periinfarct tissue. Thus, therapeutic angiogenesis has been initially studied in animal models, but there is still a long way to go for therapeutic angiogenesis to be used in the treatment of stroke patient.