原发性高血压伴肥胖病人胰岛素水平观察

Analysis of Insulin Levels in Patients with Essential Hypertension(EP) Accompanied by Obesity

探讨原发性高血压伴肥胖病人胰岛素水平变化临床意义。方法35例原发性高血压伴肥胖病人（A组）、26例单纯性肥胖病人（B组）、28例正常人（C组），以OGTT、In-st观察糖负荷前后血糖和胰岛水平变化，并计算胰岛素敏感指数（ISI），胰岛素曲线下面积（A）。结果（1）三组均是正常糖耐量曲线，其峰值分别A组＞B组＞C组；A组中检出IGT9例（25．7％）。（2）A、B两组INS明显高于值，且各时点值显著增高，ISA明显下降，A值明显增高，P＜0.05、0.001。A、B两组间于2h、3h点亦有显著性差异。原发性高血压伴肥胖症病人存在着明显高胰岛素血症和胰岛素抵抗，易诱发IGT和DM、政联合检测QGTT、In－st对临床干预治疗十分重要。

In this study, 35 patients with EP aerempanied by obesity were collected as experimental cases, 26 patients only with obesity and 28 heaithy people were collected as control cases.Their plasma insulin and glucose levets werc measured through oral plasma gulucose tolerance test (OGTT ) and insulin stimulation test (In-st ), then their insulin sensitive Indexes (ISI) and areas under insulin curves were counted. The corresponding results show that the patients with EP have obvions herperinsulinemig and resistanee to insulin,which can easily induce DM and IGT so the OGTT and In-st are very inportant to clinic interfering therapy.