摘要
采用国内已有的诺氟沙星中间体7—氯—6—氟—4—羟基喹啉—3—羧酸乙酯为起始原料,首次以1—乙氧基—1—溴环丙烷为烷化剂,四丁基溴化胺为相转移催化剂,非质子极性溶剂为介质,在喹啉环上进行N—环丙基取代反应,再经两个工序得到了环丙氟哌酸,总收率达68.5％,该法合成路线短,收率高。
Ciprofloxacin was synthesized from the intermdeiate of Norfloxacin 6-fluoro-7-chloro-4-hydroxy-3-quinolinecarboxylic Acid ethyl Ester as the starting material via condensation with 1-bromo-l-ethoxycyclopropane followed by reductive elimination of ethoxyl group and then hydrolysis,condensation with piperazine in 68.5% overall yield.
出处
《湖北师范学院学报（自然科学版）》
1998年第3期118-120,共3页
Journal of Hubei Normal University(Natural Science)
关键词
环丙氟哌酸
合成
ciprofloxacin systhesis
