血液透析患者丙型和庚型肝炎病毒感染的研究

Prevalence of HCV and HGV infection among patients undergoing hemodialysis

为了解血液透析患者中丙型肝炎病毒(HCV)和庚型肝炎病毒(HGV)的感染情况,并探讨相对危险因素,对48例在302医院和武警总医院进行维持性血液透析的患者用逆转录聚合酶链(PCR)反应和酶联免疫法检测了血清中HCV RNA、HGV RNA及其抗体水平。结果显示,抗-HCV和HCV

In order to assess the infectious status caused by hepatitis C virus (HCV) and hepatitis G virus (HGV) in patients undergoing maintenance hemodialysisi and evaluate their risk factors, 48 patients in 302 hospital and Wujing hospital dialysis units were detected by using RT- PCR to detected serum HCV RNA and HGV RNA, ELISA to detect serum anti-HCV and anti- HGV antibodies. fifty-four percent of the patients (26 of 48) was anti--HCV positive, thirty--one percent of the patients (15 of 48) was HCV RNA positive; the positive rates of anti--HGV and HGV RNA were 8% (4 of 48) and 10%(5 of 48). Among the anti--HCV negative patients, HCV RNA was detected in one of the 22 patients. Mantel-Haensze analysis showed that HCV infection was associated with multitransfusions and dialysis over a long period. Otherwith, samples of dialysate in 15 serum HCV RNA positive cases were directly detected for HCV RNA, and 3 were found HCV RNA detectable. HCV and HGV infection rates in hemodialysis patients are higher than that of general population. The main risk facter for HCV and HGV transmission is blood transfusion, the Iength of time on dialysis. The blood contaminated dialysis equiment and contaminated material are also the risk factors. The hemodialysis patients were infected by HCV or HGV should be isolated.