硝苯地平对兔体内茶碱药物动力学的影响

EFFECT OF NIFEDIPINE ON PHARMACOKINETICS OF THEOPHYLLINE IN RABBITE

为探讨硝苯地平对氨茶碱的药代动力学的影响,采用反相高效液相色谱法,测定健康家兔iv氨茶碱注射液(12.5mg·kg^(-1))和加服硝苯地平(20mg·kg^(-1))3d后氨茶碱的血药浓度。结果表明:茶碱的血药浓度为(14.52±3.70mg·L^(-1)),较单用氨茶碱的血药浓度(27.43±7.61mg·L^(-1))明显下降,AUC减小,V增大,(P<0.05)。比较两组其它药动学参数无显著性差异(P>0.05)。结论:硝苯地平对氨茶碱药动学性质未产生显著影响,合并用药不需要调整氨茶碱剂量。

In this study,serum drug concentration of theophylline was determined with reverse - phase HPLC.The concentration of theophylline was 27.43± ?3.61mg·L-1 and 14.52± ?3.70mg·L-1. With nifedip-ine respetively. The vesull showed that Nifeclipine has no notable effect on pharmcokinetic parameters of theo-phylline when the drugs are taken by combination.