立体定向放射治疗配合化疗治疗非小细胞肺癌

Stereotactic radiosurgery combined with chemotherapy for non-small cell lung cancer

目的 观察立体定向放射治疗配合化疗治疗非小细胞肺癌的近期疗效。方法 31例非小细胞肺癌患者均行 NP方案 (N:去甲长春花碱 2 5 mg/ m2 第 1 .8天给予 ;P:顺铂 6 0 - 80 mg/ m2 分 2 - 3d给予 ;2 1 d为 1个周期 )化疗加立体定向同步治疗。结果 31例全部完成治疗计划 ,肺原发灶完全缓解 (CR)占 1 9.3% ,部分缓解 (PR)占74 .2 % ,无变化和进展 (NR+PD)占 6 .5 % ,总有效 (CR+PR)率 93.5 % ;纵隔淋巴结完全缓解 (CR)占 34.2 % ,部分缓解率为 6 5 .8% ,无变化和进展 (NR+PR)占 0 % ,总有效率 (CR+PR)为 1 0 0 % ,白细胞下降率为 96 .8% ,其中 3.4级白细胞下降 4 5 .2 % ,放射性食管炎和放射性肺炎的发生率分别为 5 4 .8%和 1 2 .9% ,均为 1、2级。

Objective To evaluate short term treatment effects of sterotactic radiosurgery with chemotherapy (CT) for non-small call lung cancer (NSCLC).Methods From Sept. 1999 to Dec. 2002, 31 patients with NSCLC were treated with sterotactic radiosurgery combined with chemotherapy navelbine+cisplatin NP. Results The overall response rate (CR+PR) was 93.5% for the primary tumor, and 100% for metastatic mediastinal lymph nodes. The leucopenia rate was 96.8% (45.2% grades 3.4). Acute radiation esophagitis occurred in 54.8% of patients (Grate 1.2). Acute radiation pneumonitis was observed in 12.9% of patints (Grades 1.2).Conclusion Sterotactic radiosurgery combined with CT is effective and well tolerated for most patients with NSCLC.