嗜酸细胞性支气管炎是慢性咳嗽的一个重要原因

Eosinophilic bronchitis-an important reason for chronic cough

目的 调查门诊慢性咳嗽病人中嗜酸细胞性支气管炎的发病率。方法 对门诊慢性咳嗽 ,干咳和已用抗生素或支气管扩张剂治疗 2～ 3月的病人 ,以及查体无喘息无哮鸣音的病人 ,X胸片正常 ,肺功能正常。这些病人再进行诱导痰细胞学分析、肺功能峰流速变异率观察测定、支气管激发试验测定等 ,进行规范的程序诊断。结果 确诊嗜酸细胞性支气管炎 1 8例慢性咳嗽病人 ,肺功能 FEV1 =1 1 3± 8.2 % ;FEV1 / FEV81± 7.6 %。组织胺激发试验阴性 PC2 0 >=8mg/ ml。嗜酸细胞数占诱导痰涂片细胞总数的百分比是 2 2 .5± 1 8%。门诊嗜酸细胞性支气管炎发病率是 3.4 6 %。

Objective To explored incidence of eosinphilic bronchitis disease in chronic cough outpatients. Methods The study included outpatients with chronic cough who were treated by antibiotics and by a bronchial dilation pharmaceutical after 2 3 months and who were not examined to gasp for breath and did not have wheeze. The patients were examined by X ray and their lung functions were normal. The patients took induced sputum cell analysis test,and lung function test for peak exhale flow variation rate, challenging bronchial test, and standard diagnosis and a procedure diagnosis. Results There were 18 cases with eosinophilic bronchitis,Lung function FEV1=113±8.2%; FEV1/FEV81±7.6%. Histamine challenge test was negative at PC20>8mg/ml. The eosinophilic number was 22.5±18% of the total account cell number of induced sputum smear. The incidence of eosinophilic bronchitis disease for outpatients was 3.46%.Conclusion Eosinophilic bronchitis is an important cause for chronic cough.