妊高征免疫球蛋白G特异性激活补体类循环免疫复合物的研究

Circulating Specific IgG Immune Complexes Activating Complement in Pregnancy Induced Hypertension

目的探讨免疫球蛋白 G 特异性激活补体类循环免疫复合物(IgG/C3-CIC)在妊高征(PIH)发病中的作用。方法采用捕捉法 ELISA 测定血清 IgG/C3-CIC 水平,单向免疫扩散法测定血清 IgG 水平,正常晚期妊娠34例(对照组),妊高征81例(研究组)。结果正常足月孕妇、轻度PIH、中度 PIH 及重度 PIH 孕妇血清 IgG/C3-CIC 浓度分别为0.284±0.18、0.303±0.16、0.483±0.286及0.462±0.206,血清 IgG 浓度分别为191.07±112.92 g/L、147.56±47.91 g/L、140.18±32.89 g/L 及125.4o±53.24 g/L。中度 PIH 和重度 PIH 孕妇血清 IgG/C3-CIC 浓度高于正常足月孕妇和轻度 PIH 者(P<0.01);不同程度 PIH 孕妇血清 IgG 浓度均高于正常足月孕妇者(P<0.05)。结论妊高征患者血清 IgG/C3-CIC 浓度升高及 IgG 浓度降低。

Objective To determine circulating specific IgG immune complexes activating complement(IgG/C3-CIC)concentrations in maternal serum of normal term pregnant women and women with pregnancy induced hypertension(PIH).Methods We detect the serum level of IgG/ C3-CIC and IgG in 115 subjects,including 34 cases of normal pregnant women and 81 cases of PIH women.Results The serums concentrations of IgG/C3-CIC in normal term pregnant women, women with mild PHI,moderate PIH and serve PIH were 0.284±0.18,0.303±0.16,0.483±0.286 and 0.462±0.206,respectively.The serum concentration of IgG in the women were 191.07±112. 92g/L,147.56±47.91 g/L,140.18±32.89 g/L and 125.40±53.24 g/L,respectively.The serum concentration of IgG/C3-CIC in patients with moderate PIH and severe PIH was higher than that in patients with mild PIH and normal term pregnant women(P<0.01).The serum concentration of IgG in patients with PIH was lower than that in normal term pregnant women,P<0.05.Conch- sions The serum concentration of IgG/C3-CIC increased and the serum concentration of IgG de- creased in patients with PIH.