肺癌细胞多向分化与异质性的研究

A STUDY ON THE MULTIPOTENTIALITY IN DIFFERENTIATION AND HETEROGENICITY OF LUNG CANCER CELLS

探讨肺癌细胞多向分化与异质性。用光镜、免疫组化方法观察了87例肺癌手术标本组织切片，30例细胞涂片。（1）标本取材块数与病理分型种类多少里显著性正相关。（r=0．407，P＜0．01）；（2）作为单一类型的小细胞癌、鳞癌、腺癌、大细胞癌及类癌仅占27．6％、20％鳞癌、16．7％腺癌、23．3％大细胞癌KER、VIM双表达。66．7％有鳞、腺、神经内分泌三向分化；（3）在混合类型肺癌中，细胞学与组织学分型符合率为56．7％。肺癌细胞类型有明显异质性，其发生分子基础尚待进一步研究。

To study the multipotentiality in differentiation and heterogenicity of lung cancer cells.Eighty-seven cases of resected lung cancer and 30 cases of cytologic smears from patients with lung cancer were studied by light microscopy and immunohistochemical technique. (1)The number of drawing materials was found to be associated with the kind of classification of pathology (r=0'.407, P<0. 01) 1 (2) In the 87 cases, only 24 (27. 6% ) patients had single type as small cell, squamous, adeno, large cell carcinoma and carcinoid. The coexpression of KER+VIM of squamous, adeno, large cell carcinoma was 20. 0%, 16. 7% and 23. 3% respectively. Tumor cells having three differentiation (squamous. adeno, andneuroendocrine), accounted for 66. 7 % ; (3) The coincidence rate of cytological type and histological type was 56. 7% in mixed lung carcinoma. The cell type of lung carcinoma has marked heterogenicity, but its genie level requires further studies.