球囊拉伤兔髂动脉内膜的组织形态变化的研究

A MORPHOLOGIC STUDY OF ILIAC ARTERY INTIMA AFTER BALLOON INJURY IN RABBIT

球囊拉伤血管内膜是目前研究血管内膜增厚，管腔狭窄的方便而切实的模型。因此，对其演变过程的形态学研究是必要的。方法：应用ＰＴＣＡ球囊导管拉伤兔髂动脉，用光镜、电镜和扫描电镜观察拉伤后不同时间的动态变化。结果：拉伤后各期变化不同，拉伤后１周内，以血细胞沉积为主，１周后，内膜开始增生，２至４周增生最快。增生活跃的内膜平滑肌细胞来自活化的中膜平滑肌细胞。内皮细胞增生极慢，４周内未见内膜内皮化，呈虫食样改变。结论：球囊拉伤兔髂动脉内膜，可引起血栓形成，炎症反应，平滑肌细胞增生和细胞外基质堆积，导致血管腔狭窄。

Balloon injury vascular intima is the method used for studying vascular intima proliferation and restenosis. It is necessary to research the time course of the vascular injury morphogeny. Method: Rabbit iliac intima was injured by PTCA balloon, the time couse of the changes was observed by the light micrograph, electrograph, scanning electron micrograph. Results: There are different morphological changes in different stages. Blood cells were adhered to injured intima and the initial inflammatory response was characterized by these injured intima in 1 week after injury. Intima thickening and SMC proliferaton began at one week after injury. VSMC proliferation quickly increased in intima during 2-4 week after injury, these VSMC came from medium. But EC proliferaion was slow. There was no endothelialization in the surface of intima at 4th week. Conclusion: Balloon injury vascullar intima may cause thrombosis, inflammatory response, VSMC proliferation and matrix accumulation, which result in vascular stenosis. This study may provide some objective evidence for farther research.