呱西替沙的合成研究

Study of Synthesis of Guacetisal

以水杨酸和念创木酚为原料，在PCl3催化作用下合成水杨酰愈创木酚酯，收率由国内文献的49．5％提高至77．1％，再经乙酰化合成呱西替沙，收率96．30％。

By using PCl3 as a catalyst, salisylic acid reacted with guaiacol and synthezed into acid guaiacol ester(4) with the yield increasing from 49. 8 % to 77. 1 % as compared to the reaction without the PCl3. By then going through acetylation the acid guaiacol ester (4) was turned into guaeetisal with a yield of 96. 3%.