脑梗塞患者尼莫地平治疗前后TCD对照研究

TCD Comparative Study on the Infarction Patients by Using Nimodipine

35例脑梗塞患者经尼莫地平治疗前后进行了经颅多普勒(TCD)对照研究,治疗前发现其中27例血流速异常,异常率为82.0％。表现高血流速异常组12例(36.3％),低血流速异常组15例(45.4％)。治疗后TCD复查高血流速异常组无变化,而低血流速异常组平均血流速度增高10～15 cm·s^(-1),提示尼莫地平对脑阻力血管有调节、抗血管收缩和抗缺血作用,而对颅底狭窄段大、中等动脉无扩管和溶栓作用。

A transcranial doppler (TCD) study was carried out among 35 cerebral infarction cases with Nimodipine treatment. There were 27 cases which had abnormal blood flow (82.0%), among them 12 cases with increased blood flow (36.3%) and 15 cases with decreased blood flow (45.4%). The clinical symptoms were improved after the use of Nimodipine. TCD re-examination showed no change in increased blood flow group, in which the mean velocity of blood flow was increased by 10~t5 cm/s. It can be explained that Ni- modipine has the effect of regulation and the effect against vessel constriction and ischemia on the cerebral re- sistant vessels, but it had no thrombolysis effect and can not dilate the middle-sized and large stenosed arter- ies on the basal skull.