维拉帕米抑制气管插管时心血管反应的效应

Effect of Verapamil on the Cardiovascular Responses to Tracheal Intubation

观察不同剂量维拉帕米对减弱气管插管时心血管反应的效应。选择符合美国麻醉医师学会(ASA)Ⅰ级标准需全麻插管的患者30例,在窥喉前45s静脉给予维拉帕米0.05 mg/kg(A组)或0.1mg/kg(B组)或生理盐水(C组),麻醉诱导用25.0g/L硫喷妥纳(5 mg/kg)、维库溴铵O.2 mg/kg。结果表明,维拉帕米虽不能预防窥喉和插管时引起的心动过速,但与对照组比较可明显抑制平均动脉压(MAP)的增高(P<0.05)。

The efficacy of verapamil in attenuating the cardiovascular responses to tracheal intubation was examined in 30 of ASA I patient by giving verapamil 0. 05 mg/kg (group A) or 0. 1 mg/kg (group B) or Natrual salme (group C) intravenously 45 s before laryngoscopy. Anesthesia was induced with 25.0 g/L thiopentone 5 mg/kg i.v. and tracheal intubation was facilitated with vencuronium 0. 2 mg/kg. The increase of MAP was obviously inhibited in verapanmil-treated patients compared with those in the control group (P< 0. 05), although verapamil failed to prevent tachycardia caused by laryngoscopy and intubation