有高血压家族史儿童盐负荷后肾脏排Na^+、K^+变化规律的研究

Studies on Excretion Pattern of Ions Na^+ and K^+ from Kidney in Salt Loaded Children with Family History of Essential Hypertension

对武汉市198名4～6岁身体健康的儿童进行了盐负荷前后排尿Na＋、K＋规律的研究。结果表明：①盐负荷后，有高血压家族史儿童尿Na＋排出量及尿中Na＋／K＋比值明显低于无高血压家族史儿童，而尿K＋排出量则明显高于无高血压家族史儿童，两组间差异均有极显著意义（P＜0．01）；②采用盐负荷方法测定有高血压家族史易感儿童的尿Na＋、K＋排出量及尿Na＋／K＋比值，必须收集24h全尿，这对早期发现有肾排Na＋功能缺陷的原发性高血压儿童并及早进行干预有重要意义。

This article reports the renal excretion patterns of ions Na+ and K+ in 198 normal children aged 4~6 loaded with salt. The results showed that: ①The level of Na+ and ratio of Na+ /K+ concentration in urine were significantly lower in children with family history of essential hypertension than those without family history of essential hypertension. In contrast, the K+ level excreted from urine was significantly high-er in the former than in the latter. The difference between the two groups are significant statistically (P<0.01). ② It is necessary to collect the amount of urine over 24 h which is of great importance for early detec-tion of hereditary functional defect of excreting of Na+ and K+ and for early intervention.