摘要
目的:了解迷宫手术后早期心房钠尿肽(ANP)的变化及其临床意义。方法:选择我院行迷宫手术+二尖瓣替换术及同期双瓣置换各8例,分别于术前晚,术后当日,术后1,3,7d抽取周围静脉血4ml,用放免方法测定血浆中ANP含量,同时用Swan-Ganz导管测定心排量,中心静脉压。并将两组体外循环时间进行比较。结果:迷宫手术后当日及第1天ANP明显降低,第3,7天开始回升,但仍未达到术前水平。结论:迷宫手术后早期,ANP因左右心耳被切除,手术创伤及缺血再灌注损伤而处于较低水平,提示迷宫术后早期应加大利尿剂用量。
Objective: To study the change of plasma atrial natriuretic peptide (ANP) after modified Cox's maze operation. Methods: The levels of ANP before operation, on the operation day and 1,3,7 day after operation were measured by radioimmunoassay. Meanwhile, cardio output, central venous pressure and pulmonary capillary wedage pressure were measured by SwanGanz catheter. Results: ANP levels decreased significantly on the operation day and on the first day after operation, and they began to increase on the third and seventh day after operation. Conclusion: The reasons of the decreased level of ANP after operation are due to left and right atrial appendectomy, operation and ischemiareperfusion injuries. These findings suggest that diuretic dosage should be increased during early period after maze operation.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1997年第S1期52-54,共3页
Academic Journal of Second Military Medical University
关键词
心房钠尿肽
迷宫手术
atrial natriuretic peptide
maze operation