尼莫地平胶囊治疗急性脑梗塞21例

CLINICAL TRIAL ON TREATMENT OF 21 CASES OF ACUTE CEREBRAL INFARCTION WITH NIMODIPINE

选择发病４８ｈ内的急性脑梗塞患者３６例，分脑组织液对照组（１５例）和尼莫地平治疗组（２１例），一个疗程后进行疗效比较，并探讨尼莫地平治疗急性脑梗塞的作用。研究结果显示治疗组总有效率及神经缺损的进步分数显著高于对照组（Ｐ＜０．０５）；尼莫地平在疗程中无明显的降压作用（Ｐ＞０．０５），因此适用于急性脑血管病变，对心肌缺血引起的心电图ＳＴ段下降有明显的改善，表明尼莫地平有选择性扩张冠脉的作用。对急性脑梗塞时所产生的氧自由基，尼莫地平是一种有效的氧自由基清除剂，能防治脂质过氧化损伤，使失衡的抗氧化物酶恢复正常。本研究揭示：尼莫地平能阻滞Ｃａ２＋内流，选择性地扩张脑血管，解除血管痉挛，增加脑血流量，改善微循环，保护脑组织缺血后损伤和减轻缺血再灌流的损伤。

Thirty six patients with onset of acute cerebral infarction(ACI)within 48 hours were enrolled into the study.They were allocated to received nimodipine(n=21)or cerebral tissue fluid as control(n=15)for 1 course.Results showed that the total effective rate and progressive fraction of nerve injury in the active group were significantly higher than those in the control group.No obvious antihypertensives effect of nimodipine was observed in this study(P>0.05),indicating that nimodipine may have selective effect on dilating coronary artery.Therefore,nimodipine may be a satisfactory agent for treatment of ACI.